Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis
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منابع مشابه
Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis
During meiosis, homologous chromosomes undergo synapsis and recombination. We identify TEX15 as a novel protein that is required for chromosomal synapsis and meiotic recombination. Loss of TEX15 function in mice causes early meiotic arrest in males but not in females. Specifically, TEX15-deficient spermatocytes exhibit a failure in chromosomal synapsis. In mutant spermatocytes, DNA double-stran...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2008
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.200709057